General Research Interests

In our group we are interested in exploration and development of modern crystallographic techniques, which we apply to biologically interesting projects funded by NIH. Our main interests are :

• Crystallographic computing and Instrumentation:
• Experimental MAD and combined MIR phasing
• Phase refinement and phase extension techniques
• Automated refinement protocols and algorithms
• Difficult structures
• Compton X-ray source development
• Molecular Biology :
• The proteome of Pyrobaculum aerophilum : genomic-scale structural analysis
• The proteome of Yersenia Pestis : virulence factors
• Crystallization screens and optimization
• Crystallization Center of the NIH Mycobacterium Tuberculosis Consortium for Structural Genomics
• Neurotoxins
• Breast cancer c-terminal (BRCA) intermolecular adhesion regions 
• Lipid transport, Lipoproteins, ApoE 10k (lipid binding) fragment
• Education :
• Interactive Web tutorials (constantly expanding)
• Formal lectures on Modern Biomolecular Crystallography the University of Vienna
• Lecture notes on Physical Chemisty of Protein Crystallization (EMBL 2000)

Selected Projects

Publications

PDB files

Back to The Macromolecular Crystallography Home Page
LLNL Disclaimer
This World Wide Web site conceived and maintained by Bernhard Rupp (br@llnl.gov)
Last revised May 05, 2005 14:00
UCRL-MI-125269